Comparison of Synthetic High Density Lipoprotein (HDL) Contrast Agents for MR Imaging of Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Comparison of synthetic high density lipoprotein (HDL) contrast agents for MR imaging of atherosclerosis.
Determining arterial macrophage expression is an important goal in the molecular imaging of atherosclerosis. Here, we compare the efficacy of two synthetic, high density lipoprotein (HDL) based contrast agents for magnetic resonance imaging (MRI) of macrophage burden. Each form of HDL was labeled with gadolinium and rhodamine to allow MRI and fluorescence microscopy. Either the 37 or 18 amino a...
متن کاملHigh-density lipoprotein-based contrast agents for multimodal imaging of atherosclerosis.
Lipoproteins, natural nanoparticles, have a well-recognized biological role and are highly suitable as a platform for delivering imaging agents. The ease with which both the exterior and interior of the particles can be modified permits the creation of multifunctional nanoparticles for imaging as well as the delivery of therapeutics. Importantly, their endogenous nature may make them biocompati...
متن کاملBiodegradable synthetic high-density lipoprotein nanoparticles for atherosclerosis.
Atherosclerosis remains one of the most common causes of death in the United States and throughout the world because of the lack of early detection. Macrophage apoptosis is a major contributor to the instability of atherosclerotic lesions. Development of an apoptosis targeted high-density lipoprotein (HDL)-mimicking nanoparticle (NP) to carry contrast agents for early detection of vulnerable pl...
متن کاملThe role of level and function of High Density Lipoprotein (HDL) in Cardiovascular Diseases
High-density lipoprotein (HDL) is a set of particles with heterogeneous structures that have different functions due to various compounds including surface charge, size, lipid, and protein compounds. Several prospective epidemiological studies have demonstrated that there is a clear inverse relationship between serum HDL concentration and risk of coronary heart disease, despite this relationshi...
متن کاملMultimeric Gd-based Contrast Agents for high field MR-imaging
Introduction. MR imaging is increasingly moving to higher fields as the majority of MRI scanners used in clinics work at 3 T. Imaging at high fields brings greater signal-to-noise ratio (SNR) and its concomitant benefits of higher spatial resolution and/or reduced acquisition times. Currently employed Gd-based contrast agents are small, fast tumbling molecules with low relaxivity that decreases...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2009
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc800520d